Principal Data Scientist - AI Context Architect (Semantic & Context Engineering)

Company: Amgen
Location: Thousand Oaks
Posted on: January 14, 2026

Job Description:

Join Amgens Mission of Serving Patients At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do. Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Principal Data Scientist What you will do Lets do this. Lets change the world. In this vital role you will serve as a senior individual-contributor authority on semantic modeling, context engineering, and AI-first data science enabling high-performing classical ML, reinforcement learninginformed approaches, and generative AI systems through well-architected context . This role functions as an AI Context Architect (titled as a Data Scientist): a semantic architect who can define domain entities (e.g., payer, provider, patient, product, site, indication) and the relationships between them, so that data context reliably drive model reasoning, retrieval, and downstream decisions. You will design the semantic foundations that make AI systems accurate, explainable, governable, and performantpartnering with engineering, product, security/compliance, and domain teams across R&D, Manufacturing, and Commercial Roles & Responsibilities Semantic architecture & AI-first context modeling Define enterprise-grade semantic representations for healthcare/life-sciences concepts and specify how relationships and interactions are represented for AI consumption. Create and maintain semantic schemas / ontologies / knowledge-graph models that describe entities, attributes, constraints, and linkagesoptimized for both analytics and AI reasoning. Establish context engineering standards : how data is shaped into prompts, tools, memory, retrieval indices, and structured outputs so models behave consistently across use cases. Feature engineering & model performance (core emphasis) Lead feature engineering strategy tied directly to model performance , including feature definition, transformations, leakage prevention, stability monitoring, and explainability. Perform exploratory data analysis on complex, high-dimensional datasets to identify predictive signals and context variables that improve model robustness and generalization. Context-aware ML, GenAI, and reinforcement learninginformed approaches Build and evaluate context-aware ML/GenAI solutions , integrating semantic layers with retrieval, tools, and structured outputs. Apply reinforcement learning concepts (reward modeling, policy optimization intuition, offline evaluation, exploration/exploitation framing) to improve decisioning, ranking, orchestration, and system behaviorwithout overfitting to short-term metrics. Prototype and benchmark algorithms and approaches (classical ML, deep learning, LLM-based reasoning) and advise on scalability and production readiness . Retrieval, knowledge, and governance foundations Architect and implement retrieval and memory patterns (RAG, vector stores, knowledge graphs, session memory). Define data quality and semantic quality gates (entity completeness, relationship validity, taxonomy drift, grounding coverage) that impact downstream model reliability. Cross-functional leadership Translate domain needs into semantic AI roadmaps , aligning stakeholders on definitions, metrics, and tradeoffs. Act as a principal-level mentor and technical leader: establish standards, review semantic designs, and guide teams on best practices for context engineering and feature excellence. What we expect of you We are all different, yet we all use our unique contributions to serve patients. The professional we seek will have these qualifications. Basic Qualifications: Doctorate degree and 2 years of Data Science, Computer Science, Statistics, Applied Math, or related experience Or Masters degree and 4 years of Data Science, Computer Science, Statistics, Applied Math, or related experience Or Bachelors degree and 6 years of Data Science, Computer Science, Statistics, Applied Math, or related experience Or Associates degree and 10 years of Data Science, Computer Science, Statistics, Applied Math, or related experience Or High school diploma / GED and 12 years of Data Science, Computer Science, Statistics, Applied Math, or related experience Preferred Qualifications: 1012 years applying data science in enterprise environments with demonstrated principal-level influence (or equivalent depth of expertise). Deep expertise in semantic modeling : ontologies, taxonomies, entity resolution, knowledge graphs, metadata and data contractsbuilt for operational use. Strong understanding of machine learning fundamentals and performance drivers, especially feature engineering and evaluation rigor. Practical experience implementing RAG / retrieval / vector search / knowledge graph solutions with clear governance patterns. Working knowledge of reinforcement learning concepts and how they apply to ranking, orchestration, personalization, or decision systems (even if not pure RL production). Proficiency in Python (and strong comfort with modern data/ML stacks); ability to collaborate effectively with engineering teams on production concerns. Exceptional stakeholder management: can drive alignment on , relationships, and metrics , and communicate tradeoffs clearly. Good-to-Have Skills Experience in biotech/pharma and healthcare commercial concepts (payer/provider dynamics, formulary/coverage). Familiarity with agentic/tool-using LLM patterns, prompt management, and structured outputs. Experience with feature stores, ML observability, and robust evaluation tooling. Publications, conference talks, or thought leadership in semantic AI / knowledge systems / enterprise GenAI. Soft Skills: Excellent analytical and troubleshooting skills. Strong verbal and written communication skills Ability to work effectively with global, virtual teams High degree of initiative and self-motivation. Ability to manage multiple priorities successfully. Team-oriented, with a focus on achieving team goals. Ability to learn quickly, be organized and detail oriented. Strong presentation and public speaking skills. Certifications Cloud/AI certifications (AWS/Azure/GCP) are a plus. What you can expect of us As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan Stock-based long-term incentives Award-winning time-off plans Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies. Apply now and make a lasting impact with the Amgen team. careers.amgen.com In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information. Application deadline Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position. Sponsorship Sponsorship for this role is not guaranteed. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Keywords: Amgen, Santa Barbara , Principal Data Scientist - AI Context Architect (Semantic & Context Engineering), IT / Software / Systems , Thousand Oaks, California